Voltammetric determination of atenolol enantiomers using polyelectrolyte complexes of chitosan and chitosan succinamide with cyclodextrins.

Анотація

Nowadays, the number of people with cardiovascular diseases is dramatically increasing. Especially popular are tachycardia, arterial hypertension, etc. Pharmaceuticals based on atenolol have antiarrhythmic, antianginal, hypotensive effects. Atenolol, designated chemically as 4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetamide, is a cardio selective -adrenoblocker. In connection with the important role of atenolol, different methods of its recognition and determination have been used, such as gas chromatography coupled with mass spectrometry, spectrophotometry and flow injection analysis, etc. The use of these methods requires expensive tools and equipment, long preparation and thorough cleaning of samples. An alternative to the methods listed above is the electrochemical methods of analysis, in particular the voltammetry. Voltammetric sensors based on glassy carbon electrodes (GCE) modified by composites of polyelectrolyte complexes of chitosan and chitosan succinamide with cyclodextrins for enantioselective analysis and determination of atenolol enantiomers were studied using cyclic voltammetry (CV), and differential pulse voltammetry (DPV).