Modern aspects of creating of new potential drugs based on QuS-program development.

Анотація

Development of drugs – is a unique multidisciplinary process aimed at creating of a new therapeutic agent with the most useful and safe properties. In the world practice development of original drug includes two functionally related stages: 1 – Study and 2 – The introduction or creation. In the first stage there is a discovery or synthesis of the new molecule of potential drug. Most of the new potential drugs (lead compounds) are discovered with using of one of three approaches: 1) chemical modification of known molecules; 2) screening of biological activity of a large number of natural compounds or their modifications; 3) direct synthesis based on the understanding of biological mechanisms, chemical structure and physical-and-chemical properties of the substance. Expenditures for the synthesis, screening and further preclinical and clinical studies of potential drug, amount up to 800-1000 millions of dollars. The duration of such studies 7–10 years.