In vitro activity of novel 1,3-oxazole derivatives against human papillomavirus.

Анотація

Chemotherapeutic approaches to the control of HPV (human papillomavirus) infection suffer from a lack of specificity. For most existing HPV inhibitors, the weak antiviral effects observed in cellular assays suggest that further improvements in selecting targets, in drug potency, and in bioavailability and cell uptake are required. Substituted 1,3-oxazoles can exert various biological effects and have significant antiviral activity.

The present study is an exploratory investigation of anti-HPV activity by novel 1,3-oxazole derivatives (1,3-oxazol sulfonamides and 5-amino-1,3-oxazole-4-carbonitriles) designed and synthesized in Kyiv, with all the cytotoxicity and efficacy tests performed in the the National Institute of Allergy and Infectious Diseases (USA).