Voltammetric sensor for determination of propranolol in biological fluids.
Автор(и)
Yu. G. Fayzullina
Department of Chemistry, Bashkir State University, Ufa, Zaki Validi, 32, Bashkortostan, 450076
A. I. Khabletdinova
Department of Chemistry, Bashkir State University, Ufa, Zaki Validi, 32, Bashkortostan, 450076
R. A. Zilberg
Department of Chemistry, Bashkir State University, Ufa, Zaki Validi, 32, Bashkortostan, 450076
Анотація
Propranolol is a widely used β-adrenoblokcer, which is prescribed for the treatment of hypertension, cardiac arrhythmia, and prevention of secondary myocardial infarction. Propranolol is used in sports and other stressful situations, acting as a doping agent. Propranolol and its analogues contribute to the development of an antianginal effect, which is manifested by an improvement in the state of the heart muscle, a decrease in the amount of oxygen necessary for its work. This means that the heart requires less oxygen to contract, and the frequency of these reductions also decreases. The drug slows the heart rate in animals, which leads to its use in the race industry. Because of its properties, propranolol is prohibited during the competitive period in certain sports (motor sport, billiard sports, golf, darts, skiing / snowboarding, scuba diving). It is not allowed to use it all the time in the following sports: shooting and archery. It is rapidly metabolized after administration, therefore traces of the drug in biological fluids can be detected with great difficulty some time after the intake. Detection of metabolites and drug residues can provide evidence of the use of doping.
