CD study of the iron(II) clathrochelates with terminal alkyl carboxy or sulfonyl groups in the presence of proteins.

Автор(и)

  • S. V. Vakarov Institute of General and Inorganic Chemistry
  • N. V. Chornenka Institute of General and Inorganic Chemistry
  • E. Gumienna-Kontecka Uniwersitet Wroclawski, Wroclaw
  • Y. Z. Voloshin Nesmeyanov Institute of Organoelement Compounds RAS, Moscow
  • V. B. Kovalska Institute of Molecular Biology and Genetics

Анотація

Clathrochelate complexes are the class of compounds that has shown a range of biologically active properties. Various studies show that nature of terminal ribbed functional groups is playing key role in its activity. In our recent study [1] we discovered that clathrochelate molecules bearing aryl carboxygroups form supramolecular complexes with serum albumins, in which inherently achiral clathrochelate molecule gives pronounced CD response. This occurs due to stabilization of the clathrochelate framework in one of selected chiral conformers in protein binding site and electrostatic interactions is very important for such binding. As continuation of this work we studied if exchange of terminal aryl carboxygroup to other types of functional ionizable groups make clathrochelate molecules CD sensitive to proteins.

Посилання

V.B. Kovalska, S.V. Vakarov, M.V. Kuperman, M.Y. Losytskyy, E. GumiennaKontecka, Y.Z. Voloshin and O.A. Varzatskii, Induced chirality of cage metal complexes switched by their supramolecular and covalent binding, Dalton Trans, 2018, 47, 1036-1052.

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Медична та фармацевтична хімія