The study of N-alkyl functionalized indolenine based squaraines as fluorescent probes for proteins detection.
Автор(и)
A. S. Syniuhina
Taras Shevchenko National University of Kyiv
Institute of Molecular Biology and Genetics NASU
S. V. Chernii
Institute of Molecular Biology and Genetics NASU
Yu. L. Slominskii
Institute of Organic Chemistry, National Academy of Scinces of Ukraine NASU
S. M. Yarmoluk
Institute of Molecular Biology and Genetics NASU
Анотація
Squaraine dyes are widely studied as potential fluorescent probes for the labelling and detection of biomolecules, including proteins. Detection of proteins could be useful for chemical and biochemical analyses, biotechnology and immunodiagnostics. Serum albumins are multifunctional proteins present in the blood serum of animals, which bind and transport a variety of ligands. The study of interactions between dye and serum albumins is important for research as a simple diagnostic method for biochemical systems, because albumins concentration could be used as diagnostic parameter.