Synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead nitrogen atom.

Анотація

For many years, sulfonamide-derived drugs were dramatically prevailed by aromatic derivatives. However, the recently increased interest to synthesis of their aliphatic counterparts provides an access to yet underexplored parts of pharmaceutically relevant chemical space. Although biologically active five- and six-membered alicyclic sulfonamides were reported in hundreds of papers and patents, their polycyclic analogues remain scarce in the literature. Two approaches to synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead Nitrogen atom were developed.