Neuroprotective efficacy of the thiamine high dose administration in cornea of chronically alcoholized rats
The cornea is the most densely innervated structure in the body. Corneal nerves perform sensory functions, regulates reflex tear production, blinking, and the release of trophic factors. Among many negative effects on the eye, long-term ethanol (EtOH) consumption may induce damage to corneal nerves and cause epithelial defects leading to vision impairments and possible blindness. Several mechanisms have been proposed to explain EtOH-related corneal injury, and B1 (thiamine) hypovitaminose caused by EtOH is one of the predominant. Thus, the aim of the present study was to investigate if thiamine high dose is able to alleviate EtOH-induced corneal neurotoxicity in chronically alcoholized rats.