Energetics of 3-(1,5-diphenyl-1H-pyrrol-2-yl)propanoic acid derivatives
Анотація
Polysubstituted pyrrole derivatives, in particular arylpyrroles, are capable of exhibiting biological activity. Such compounds are part of a number of drugs characterized by antitumor, antibacterial, analgesic, antioxidant and anti-inflammatory properties. In the chemical industry, such compounds can be used in the production of electrically conductive and optoelectronic materials, plant protection products. A key aspect of their potential use as drug components is the diversification of biological activity due to electrophilic substitution reactions, which is caused by the aromatic nature of the pyrrole ring. Among these compounds, the ability to exhibit biological activity was predicted for 3-(1,5-diphenyl-1H-pyrrol-2-yl)propanoic acid derivatives [1]. The lack of values of the enthalpy of formation in the condensed state in the reference literature prompted us to determine them experimentally. The availability of this fundamental thermodynamic parameter will allow to carry out optimization calculations for synthesis and processing processes for technological purposes.
Посилання
Sitar A., Shevchenko D., Matiichuk V., Skrypska O., Lesyuk O., Khomyak S., Lytvyn R., Sobechko I., Horak Yu. (2024). Synthesis of 3-(1R-5-phenyl-1H-pyrrol-2-yl)propanoic acids and prediction of their biological activity. Visnyk of the Lviv University. Series Chemistry, 65(1), 223–230. https://doi.org/10.30970/vch.6501.223 (in Ukrainian)