Projection to latent structures for recognition of atenolol by manufacturers.
Автор(и)
L. R. Kabirova
Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
Yu. R. Provorova
Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
D. I. Dubrovsky
Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
A. I. Habletdinova
Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
L. R. Ganieva
Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
Анотація
Atenolol is a selective β1-adrenoblocker. It is used in the treatment of cardiovascular diseases, such as arterial hypertension, angina pectoris, acute myocardial infarction, tachycardia, etc. One of the enantiomers of the medicinal product has pronounced pharmacological properties, unlike the other. This stimulates the development of studies on the recognition and determination of atenolol enantiomers in pharmaceuticals. In this work, pharmaceuticals from various manufacturers (Belupo, Pranapharm etc.) were chosen as real samples. The voltammograms were obtained by oxidation of atenolol on glassy carbon electrodes (GCE) modified by composites of polyelectrolyte complexes of chitosan (CS) and chitosan succinamide (SCS) with cyclodextrins (CD).
