Identification of atenolol based agents in real objects using the principal component method.

Анотація

One of the most common diseases to date, are diseases of the cardiovascular system. Such as arterial hypertension, tachycardia, arrhythmia, etc. Atenolol is a medicinal product that helps fight these diseases. Chemically, atenolol is designated as 4-(2-hydroxy-3- isopropylaminopropoxy) phenylacetamide, is a cardioselective b-adrenergic blocker. Biological activity depends on one of the enantiomers. In particular, for atenolol, the Senantiomer is 50–500 times more effective than the R-enantiomer. Various methods are used for the recognition and determination of enantiomers in drugs: gas chromatography in combination with mass spectrometry, spectrophotometry and analysis of injection of a stream, etc. But the above methods are expensive in equipment, long-term preparation of samples that require highly qualified specialists, etc. These problems are solved by electrochemical methods of analysis, in particular voltammetry.