Studying of influence of some antibiotics of a cephalosporin series on the process of enzyme hydrolysis of chitozan in the solution of acetic acid.

Анотація

Nowadays one of the perspective directions of the use of chitosan (ChT) is the creation of the film materials on its basis including drugs for the treatment of surgical, burnt and sore wounds. In the conditions of medical application of chitosan materials their biodestruction is carried out under the influence of nonspecific enzymes of a human body (for example, hyaluronidase) and defines covering service life on a wound surface. In the works of previous years we defined some kinetic characteristics of the activity of enzyme hyaluronidase for the reaction of enzyme hydrolysis of ChT in the solution of 1 % acetic acid, and also in the presence of antibiotics of an aminoglycoside series - amikacin and gentamycin. This work is undertaken with the purpose of the expansion of some medical substances (MS) immobilized in a polymeric matrix.