Polarographic determination of nicotine, in the form ofn-oxide, inspray «nicorette»
Nicotine (3-(2S)-1-methylpyrrolidin-2-yl)-pyridinе) –one of the representative of the alkaloids of the pyridine series. It is contained in the leaves and stems of tobacco and other members of the nightshade family of plants and in cigarettes, cigars and refills for electronic cigarettes. Nicotine acts on the central nervous system, makes a person feel more relaxed. This effect is one of the features desired by smokers, which leads to their regularuse of tobacco products containing nicotine. As a substance, nicotine is toxic and causes paralysis of the nervous system. Prolonged use of nicotine leads to hyperglycemia, hypertension, tachycardia, heart failure and myocardial infarction. It should be noted that nicotine as a substance does not cause cancer, butaccelerates the growth and migration of existing cancer cells and promotes the transformation of some precancerous cells into cancer.
Dubenska L., Dushna O., Pysarevska S., Blazheyevskіy M. A new approach for voltammetric determination of nefopam and its metabolite. Electroanalysis. 2020.Vol. 32, No3.P. 626–634.DOI: https://doi.org/10.1002/elan.201900595