The discovery of metallothioneins response in the synovial tissues of rats under the acute gonarthritis
Metallothioneins are the unique heat-stable intracellular proteins of particular composition. They are buffering the Zinc (Zn) withing the cell providing its regulatory transfer to other cellular targets. The inflammation processes are frequently accompanied by the Zn deficiency in the body. There are plural data witnessing a continuous deficiency of Zn inserum and plasma of patients with inflammation.However, to the best of our knowledges, the ability to accumulate Zn in the metallothioneins under the gonarthritis (GA) was not investigated. Moreover, the efflux of metallothioneins from the cells can be expected under the inflammation, but the presence of these proteins in the synovial tissues was not in the focus of studies. Therefore, the aim of this study was to evaluate the presence of metallothioneins in the synovial tissues of rat with induced GA.