The effect of common surface waters contaminants, pesticide roundup and drug chlorpromazine, in the environmentally relevant exposures on the bivalve mollusk Unio tumidus
Bivalve mollusks represent the most recognized bioindicators of the surface water chemical pollution and climate changes. However, the specific responses of mollusk to certain xenobiotics are not well understood and examined mostly in the experimental acute exposures to single substanses in the environmentally impossible high concentrations. This study aimed to compare the subchronic impact of common aquatic pollutants in the single and combine exposures utilizing the low environmental concentrations and toreveale the common and particular responses. Both selected substances, herbicide Roundup (the commercial composition of glyphosate) and drug chlorpromazine, are the pollutants of priority. Both substances are expected to impact the metal homeostasis, namely calcium uptake and zinc (Zn) metabolism with the realtion on the general transporting systems. Elevated temperature was shown to exacerbate the toxicity or distort effects of xenobiotics in different exposures of bivalve mollusks including the mixture contained Roundup. However, the limits of adaptive responses to combine effect of pollution and the temperature extreames are not well understood now.