Cu-catalyzed formation of pyridines from propargylamine and cycloalkanones
Aromatic heterocycles fused with saturated cyclic hydrocarbon ring are important building blocks for medical chemistry due to their potential biological activity . Such compounds can be obtained in the reactions of propargylamine and cycloalkanones catalyzed by Au(I) salts . The development of noble-metal-free and reliable methods for synthesis of multi-gram amounts of the such aromatic heterocycles is important task of modern organic chemistry and catalysis. The aim of this study was to find optimal conditions for Cu-catalyzed formation of pyridines by cyclization reaction from propargylamine and cycloalkanones.
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