Cu-catalyzed formation of pyridines from propargylamine and cycloalkanones

Автор(и)

  • S. O. Sotnik Enamine Ltd, Kyiv, L.V. Pisarzhevskii Institute of Physical Chemistry of the National Academy of Sciences of Ukraine, 3National Taras Shevchenko University of Kyiv
  • A. I. Subota Enamine Ltd, Kyiv, Institute of Organic Chemistry, National Academy of Sciences of Ukraine
  • A. S. Lytvynenko L.V. Pisarzhevskii Institute of Physical Chemistry of the National Academy of Sciences of Ukraine
  • S. V. Kolotilov L.V. Pisarzhevskii Institute of Physical Chemistry of the National Academy of Sciences of Ukraine, National Taras Shevchenko University of Kyiv
  • S. V. Ryabukhin Enamine Ltd, Kyiv, National Taras Shevchenko University of Kyiv
  • D. M. Volochnyuk Enamine Ltd, Kyiv, National Taras Shevchenko University of Kyiv, Institute of Organic Chemistry, National Academy of Sciences of Ukraine

Анотація

Aromatic heterocycles fused with saturated cyclic hydrocarbon ring are important building blocks for medical chemistry due to their potential biological activity [1]. Such compounds can be obtained in the reactions of propargylamine and cycloalkanones catalyzed by Au(I) salts [2]. The development of noble-metal-free and reliable methods for synthesis of multi-gram amounts of the such aromatic heterocycles is important task of modern organic chemistry and catalysis. The aim of this study was to find optimal conditions for Cu-catalyzed formation of pyridines by cyclization reaction from propargylamine and cycloalkanones.

Посилання

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Опубліковано

2021-05-08

Номер

2021

Розділ

Органічна хімія