Synthesis of N,N'-disubstituted thioureas as intermediates for synthesis of 1,3-thiazol-2(3H)-imine derivatives.

Анотація

The Hantzsch condensation reaction was the first method employed for the synthesis of 2-aminothiazole moiety using an α-haloketone and thiourea as starting materials. N-alkylated imino-thiazolines could be obtained by replacing thioureas with mono and N,N-disubstituted thioureas under different reaction conditions. In continuation of our work on searching for biologically active substances among 2-Rphenylіmіno-1,3-thіazoline derivatives we planned to combine 2-R-phenylіmіno-1,3-thіazoline and N-methylpiperazine moiety in one molecule and synthezise a series of 4-(R-phenyl)-N-(R`- phenyl)-3-(4-methyl-1-piperazinyl)-1,3-thiazol-2(3H)-imine derivatives. To achieve this purpose we planned to synthezise the intermediates – 1-(4-methylpiperazin-1-yl)-3-Rphenylthioureas for synthesis of target compounds.