Synthesis of N,N'-disubstituted thioureas as intermediates for synthesis of 1,3-thiazol-2(3H)-imine derivatives.
Authors
H. O. Yeromina
National University of Pharmacy
L. O. Perekhoda
National University of Pharmacy
Z. G. Ieromina
National University of Pharmacy
I. A. Sych
National University of Pharmacy
L. A. Grinevich
National University of Pharmacy
Abstract
The Hantzsch condensation reaction was the first method employed for the synthesis of 2-aminothiazole moiety using an α-haloketone and thiourea as starting materials. N-alkylated imino-thiazolines could be obtained by replacing thioureas with mono and N,N-disubstituted thioureas under different reaction conditions. In continuation of our work on searching for biologically active substances among 2-Rphenylіmіno-1,3-thіazoline derivatives we planned to combine 2-R-phenylіmіno-1,3-thіazoline and N-methylpiperazine moiety in one molecule and synthezise a series of 4-(R-phenyl)-N-(R`- phenyl)-3-(4-methyl-1-piperazinyl)-1,3-thiazol-2(3H)-imine derivatives. To achieve this purpose we planned to synthezise the intermediates – 1-(4-methylpiperazin-1-yl)-3-Rphenylthioureas for synthesis of target compounds.
