Principal component analysis for selective voltammetric recognition of atenolol enantiomers.

Автор(и)

  • R. A. Zilberg Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
  • Yu. R. Provorova Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
  • L. R. Kabirova Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
  • A. I. Habletdinova Bashkir State University 32, Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia

Анотація

Atenolol (ATN) is a drug that helps to fight the diseases of the cardiovascular system. It has antiarrhythmic, antianginal, hypotensive biological actions. Biological activity of drugs is associated with one of the enantiomers. For atenolol, the S-enantiomer is usually 50–500 times more effective than the R-enantiomer.

In this study, voltammetric sensors based on glassy carbon electrodes (GCE) modified by composites of polyelectrolyte complexes of chitosan and chitosan succinamide (CS-SCS) with cyclodextrins (CD) for the recognition of ATN enantiomers have been developed. For more reliable recognition of enantiomers and their racemic mixtures, the obtained voltammograms were chemometrically processed using the principal component analysis (PCA).

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Номер

2018

Розділ

Аналітична хімія