Principal component analysis for selective voltammetric recognition of atenolol enantiomers.
Abstract
Atenolol (ATN) is a drug that helps to fight the diseases of the cardiovascular system. It has antiarrhythmic, antianginal, hypotensive biological actions. Biological activity of drugs is associated with one of the enantiomers. For atenolol, the S-enantiomer is usually 50–500 times more effective than the R-enantiomer.
In this study, voltammetric sensors based on glassy carbon electrodes (GCE) modified by composites of polyelectrolyte complexes of chitosan and chitosan succinamide (CS-SCS) with cyclodextrins (CD) for the recognition of ATN enantiomers have been developed. For more reliable recognition of enantiomers and their racemic mixtures, the obtained voltammograms were chemometrically processed using the principal component analysis (PCA).