Synthesis and study of the bioactivity of phthalocyanines modified with axial dehydroacetic acid moieties.

Автор(и)

  • S. Chernii Institute of Molecular Biology and Genetics NASU
  • I. Tretyakova
  • M. Losytskyy Institute of Molecular Biology and Genetics NASU
  • Yu. Gerasymchuk Institute of Low Temperature and Structure Research PAS
  • V. Chernii V. I. Vernadskii Institute of General and Inorganic Chemistry NASU
  • V. Kovalska Institute of Molecular Biology and Genetics NASU

Анотація

Phthalocyanines are widely studied for their biological activity; in particular, they have been shown antibacterial activity, antiprionic and antifibrilogenic properties. The spontaneous protein self-assembly into amyloid fibrils, characterizes a number of pathologies, including neurodegenerative diseases. The search for the agents that are able to suppress or redirect fibril formation could be useful for controlling protein aggregation.

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Неорганічна хімія