Synthesis and study of the bioactivity of phthalocyanines modified with axial dehydroacetic acid moieties.
Authors
S. Chernii
Institute of Molecular Biology and Genetics NASU
I. Tretyakova
M. Losytskyy
Institute of Molecular Biology and Genetics NASU
Yu. Gerasymchuk
Institute of Low Temperature and Structure Research PAS
V. Chernii
V. I. Vernadskii Institute of General and Inorganic Chemistry NASU
V. Kovalska
Institute of Molecular Biology and Genetics NASU
Abstract
Phthalocyanines are widely studied for their biological activity; in particular, they have been shown antibacterial activity, antiprionic and antifibrilogenic properties. The spontaneous protein self-assembly into amyloid fibrils, characterizes a number of pathologies, including neurodegenerative diseases. The search for the agents that are able to suppress or redirect fibril formation could be useful for controlling protein aggregation.
