Synthesis of 7-deazahypoxanthine derivatives and evaluation of their activity against xanthine oxidase

Abstract

Xanthine oxidase is a key enzyme in purine metabolism catalysing the conversion of hypoxanthine and xanthine to uric acid with production of superoxide radical. The increased enzyme activity leads to hyperuricemia, gout, inflammatory and cardiovascular diseases. Allopurinol and febuxostat are xanthine oxidase inhibitors that are widely used in clinical practice, but they have adverse effects. Therefore the search for new xanthine oxidase inhibitors remains relevant. Among purine isosteres, 7-deazahypoxanthine was known to be a xanthine oxidase inhibitor.