Stability of organozinc compounds over time

Authors

  • M. O. Ivanytsya L. V. Pisarzhevskii Institute of Physical Chemistry of the National Academy of Sciences of Ukraine, Enamine Ltd, National Taras Shevchenko University of Kyiv, Kyiv, Ukraine
  • M. A. Nechaev Enamine Ltd, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
  • M. M. Filippov Enamine Ltd, National Taras Shevchenko University of Kyiv, Kyiv, Ukraine
  • A. R. Velbovets Enamine Ltd, National Taras Shevchenko University of Kyiv, Kyiv, Ukraine
  • S. V. Kolotilov L. V. Pisarzhevskii Institute of Physical Chemistry of the National Academy of Sciences of Ukraine, Enamine Ltd, Kyiv, Ukraine
  • S. V. Ryabukhin Enamine Ltd, National Taras Shevchenko University of Kyiv, Kyiv, Ukraine
  • D. M. Volochnyuk Enamine Ltd, National Taras Shevchenko University of Kyiv, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Abstract

Organozinc reagents are highly reactive yet functional group-tolerant carbon nucleophiles rendering them valuable in Reformatsky reactions, Negishi cross-couplings, Michael additions, and related transformations. However, at present the organozinc reagents are usually generated immediately before use (or even in situ), due to limited data on their stability. Such a situation is a serious obstacle for broader application of such compounds and their transfer into the category of commercially available reagents.

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Published

2024-04-04

Issue

2024

Section

Organic Chemistry