Synthesis of new pyrrole derivatives on the basis of pyrrole-2- carboxaldehyde

Abstract

Compounds containing heterocyclic and carbocyclic aromatic systems are the significant compounds in organic chemistry. Recent years, the application of five and sixmembered heterocycles has been expanded in different areas of chemistry like coordination chemistry, drug design and development and material science. The pyrrole scaffold is the most essential five-membered heteroaromatic ring system between the nitrogen heterocycles. Pyrrole is important structural part of porphyrin rings which act as a key moiety of many natural compounds as heme and related cofactors (chlorophyll a, heme b, vitamin B12, factor 430) and other bioactive molecules such as porphobilinogen, nargenicin and prodigiosin. Different pharmacophores active compounds, such as elopiprazole, lorpiprazole, isamoltane, obatoclax contain pyrrole ring system.