Reaction of chlorobutanoylferrocene with 2,4 dinitrophenylhydrazine

Abstract

To date, important compounds incorporating a substituted 1,4,5,6-tetrahydropyridazine moiety include agents such as the natural antibacterial drugs, as well as a progesterone receptor ligands and a cannabinoid receptor antagonists CB1 [1]. On the other hand, a recent review [2] shows the structures of dozens of promising ferrocene-containing drug candidates against various types of cancer, malaria, pathogenic bacteria and fungi, viral diseases, and much more. In our work, we found a way to combine such important pharmacophore fragments as ferrocene and tetrahydropyridazine in one molecule.