Hetaryl and aryl derivatives of 3,3'-diindolylmethane as promising components of antimicrobial drugs

Authors

  • V. O. Vereshchak Division of Functional Materials Chemistry, State Scientific Institution "Institute for Single Crystals" of NAS of Ukraine, National Technical University "Kharkiv Polytechnic Institute", Kharkiv, Ukraine
  • A. V. Tsygankov Division of Functional Materials Chemistry, State Scientific Institution "Institute for Single Crystals" of NAS of Ukraine, National Technical University "Kharkiv Polytechnic Institute", Kharkiv, Ukraine
  • V. M. Vakula Division of Functional Materials Chemistry, State Scientific Institution "Institute for Single Crystals" of NAS of Ukraine, Department of Medical Chemistry of the State Institution "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv, Ukraine
  • V. V. Lipson Division of Functional Materials Chemistry, State Scientific Institution "Institute for Single Crystals" of NAS of Ukraine, Department of Medical Chemistry of the State Institution "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv, Ukraine

Abstract

Resistance to antimicrobial drugs and the emergence of multiresistant bacterial strains is a problem of global importance. Recent studies of 3,3'-diindolylmethane (DIM) and some of its derivatives proved the feasibility of finding new effective inhibitors for the formation of resistant biofilms by pathogenic microorganisms from the ESKAPE group [1]. In addition, information on the effect of bisindole on the synthesis of nucleic acids can become a prerequisite for a wide spectrum of antimicrobial activity of its derivatives [2].

References

Golberg, K. Anti-virulence activity of 3,3’-diindolyl-methane (DIM): a bioactive cruciferous phytochemical with accelerated wound healing benefits. Pharmaceutics. 2022, 14, pp 967–989.

Jacobs, M. R. Novel bis-indole agents active against multidrug-resistant Acinetobacter baumannii. Diagn. Microbiol. Infect. Dis. 2011, 69, pp 114–116.

Penieres-Carrillo, J. G. Synthesis of novel benzimidazole-diindolylmethane hybrid compounds within the green chemistry context. Arkivoc. 2017, 4, pp 210–221.

Downloads

Published

2024-04-08

Issue

Section

Organic Chemistry