Synthesis of pyrido[1,2-a]pyrimido[4,5-d]pyrimidine derivatives and evaluation of their inhibitory activity against acetylcholinesterase

I. I. Biletskii; L. V. Muzychka; O. V. Muzychka; O. B. Smolii

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I. I. Biletskii V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
L. V. Muzychka V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
O. V. Muzychka V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
O. B. Smolii V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine

Abstract

Pyrido[1,2-a]pyrimidine derivatives are an important class of bicyclic heterocycles with diverse biological activities. In addition, their use has been reported in the synthesis of tricyclic fused compounds, such as SARS-CoV-2-M Pro, SPOP, and chitinase inhibitors.

Synthesis of pyrido[1,2-a]pyrimido[4,5-d]pyrimidine derivatives and evaluation of their inhibitory activity against acetylcholinesterase

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