Synthesis and in silico permeability analysis using the BOILED-Egg model for (E)-1-(2-((2-(1-(2-amino-4-methylthiazol-5-yl) ethylidene)hydrazinyl)methyl)-4-methylthiazol-5-yl)ethanone

Authors

  • E. Z. Huseyinov Baku State University, Baku, Azerbaijan
  • A. S. Safarova Baku State University, Baku, Azerbaijan
  • Kh. A. Asadov Baku State University, Baku, Azerbaijan
  • A. M. Maharramov Baku State University, Baku, Azerbaijan
  • F. M. Abdullayeva Azerbaijan State Oil and Industry University, Baku, Azerbaijan, Ministry of Science and Education of the Republic of Azerbaijan, Institute of Petrochemical Processes named after academician Y. G. Mamedaliyev

Abstract

The synthesis of new thiazole-containing compounds is of significant interest in medicinal chemistry due to their wide range of potential biological activities. Incorporation of a hydrazone fragment into the structure contributes to the expansion of the molecule’s pharmacological profile by enabling the formation of specific interactions with biological targets.

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Published

2026-04-14

Issue

2026

Section

Organic Chemistry