Novel thiazolo[2,3-b]pteridines as promising luminescent probes for medicine and biology

Authors

  • D. Kyrylova Oles Honchar Dnipro National University, Nauky Ave. 72, Dnipro, Ukraine
  • O. Voskoboinik National University «Zaporizhzhia Polytechnic», Zhukovskyi st. 64, Zaporizhzhia, Ukraine
  • A. Tatarets Institute of Organic Chemistry of the NAS of Ukraine, Ak. Kukharya Str. 5, Kyiv, Ukraine
  • L. Havryshchuk Ivano-Frankivsk National Medical University, Halytska st., 2, Ivano-Frankivsk, Ukraine
  • S. Shishkina Institute of Organic Chemistry of the NAS of Ukraine, Ak. Kukharya Str. 5, Kyiv, Ukraine
  • S. Okovytyy Oles Honchar Dnipro National University, Nauky Ave. 72, Dnipro, Ukraine
  • S. Kovalenko Oles Honchar Dnipro National University, Nauky Ave. 72, Dnipro, Ukraine

Abstract

Pteridines are an important class of molecules that act as key natural metabolites and are widely used in medical practice as drugs and intermediates in the search for biologically active compounds, biomarkers, and indicators1-3. In recent years, during the screening of biologically active compounds among 6,7-disubstituted-2-thioxo-2,3-dihydropteridine-4(1H)-ones, their ability to emit blue light in polar solvents was observed4. This finding prompted the search for compounds with luminescent properties within this class. The aim of the present study was the synthesis and investigation of the fluorescent properties of 7-aryl-(hetaryl)iden-10H-thiazolo[2,3-b]pteridine-8,10(7H)-diones, considering their potential application as dyes or fluorescent probes.

References

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Carmona-Martínez V. at al. Therapeutic potential of pteridine derivatives: A comprehensive review. Med. Res. Rev. 2019; 39: 461. https://doi.org/10.1002/med.21529.

Wan Y.-Q., Tang L.-J., Tan T. Simultaneous Determination of Xanthopterin and Isoxanthopterin in Human Urine by Synchronous Fluorescence Spectroscopy. J. Fluoresc. 2010; 20: 1191. https://doi.org/10.1007/s10895-010-0667-4.

Kazunin M. S. at al. Тhio-containing pteridines: Synthesis, modification, and biological activity. Arch. Pharm. 2022; 355: e2200252. https://doi.org/10.1002/ardp.202200252.

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Published

2026-04-15

Issue

2026

Section

Organic Chemistry