Synthesis of new pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidine-based acetylcholinesterase inhibitors

Authors

  • L. V. Muzychka V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
  • O. V. Muzychka V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
  • O. B. Smolii V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine

Abstract

Alzheimer's disease is a prevalent type of dementia characterized by progressive memory loss. Inhibition of acetylcholinesterase is crucial for improving cognitive function in patients with Alzheimer's disease. FDA-approved drugs, such as donepezil, that inhibit acetylcholinesterase are used for the symptomatic treatment of Alzheimer's disease.

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Published

2026-04-15

Issue

2026

Section

Organic Chemistry