Study of electrochemical turning of the triazide drug by voltamperometric methods and mass spectroscopy.

Authors

  • A. V. Ivoilova Ural Federal University named after the First President of Russia Boris N. Yeltsin, Yekaterinburg
  • A. N. Tsmokalyuk Ural Federal University named after the First President of Russia Boris N. Yeltsin, Yekaterinburg
  • L. V. Mikhalchenko Institute of Organic Chemistry named after N. D. Zelinsky of RAS, Moscow
  • A. V. Ivanova Ural Federal University named after the First President of Russia Boris N. Yeltsin, Yekaterinburg
  • A. N. Kozitsina Ural Federal University named after the First President of Russia Boris N. Yeltsin, Yekaterinburg
  • V. L. Russinov Ural Federal University named after the First President of Russia Boris N. Yeltsin, Yekaterinburg

Abstract

"Triazide" – 5-methyl-6-nitro-7-oxo-1,2,4-triazolo [1,5-a] pyrimidine-arginine monohydrate (Fig. 1a) is a new effective antiviral drug of the azolazazine class, which is currently undergoing clinical trials at the Research Institute of Influenza (St. Petersburg). According to published data, preparations containing a nitro group show antiviral activity due to its light reducing ability and the presence of intermediate metabolites of a radical nature, which, interacting with the RNA of the virus, destroy it. Therefore, the study of the recovery process of the drug is a great interest. Electrochemical methods have proven themselves in the study of redox transformations of organic compounds and, in some cases, in combination with other methods, allow the intermediate products of these transformations to be fixed.

References

A.V. Bausheva, A.N. Tsmokalyuk, K.S. Savateev, E.K. Voinkov, E.N. Ulomsky, A.B. Ivanova, A.N. Kozitsina, V.L. Rusinov / Collection of articles on materials from the

Intern. conf.MOBI-ChemPharma 2017. - “Pero”, 2017. - 95 p.

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Issue

2019

Section

Analytical Chemistry