Merocyanines as fluorescent probes for the detection in microscopy

Abstract

Nowadays, the study of the drug distribution in cells is becoming an increasingly actual method of biomedical research. Far-red fluorescent probes are highly applicable due to certain advantages such as minimum photo-damaging of biological samples, high tissue penetration and allow imaging with minimal to no autofluorescence. The aim of the research was to study the novel series of far-red merocyanine dyes containing modified polymethine bridges by fluorescence microscopy.