Synthesis of new iron(II) bis-α-dioximate of chugaev’s type and of its macrocyclic derivative as the reactive precursor of polyaromatic clathrochelates

Abstract

Iron(II) clathrochelates are promising type of macrocyclic complexes. In recent years they are proposed as prospective agents in medicinal chemistry and biochemistry: clathrochelates can inhibit the transcription of T7 RNA polymerase, possess antiamyloidogenic activity and suggest as ICD-reporters for globular proteins. Clathrochelates of two types have been earlier used for these purposes: the triribbed-functionalized cage complexes with equivalent chelate fragments and their non-equivalent monoribbedfunctionalized bis-α-benzyldioximate analogs. Now, we obtained, for the first time, the phenanthrene-based non- and macrocyclic iron(II) bis-α-dioximates. Such a minor modification of the macrocyclic framework could lead to significant biological activity changes of further clathrochelate complexes.