Fluorescence and molecular docking study of the complexes between fibrillized insulin and lysozyme

Автор(и)

  • O. A. Zhytniakivska V. N. Karazin Kharkiv National University
  • U. K. Tarabara V. N. Karazin Kharkiv National University
  • K. O. Vus V. N. Karazin Kharkiv National University
  • V. M. Trusova V. N. Karazin Kharkiv National University

Анотація

During the past decades increasing attention has been given to elucidating the determinants of the toxic potential of amyloid fibrils, the deposition of which is associated with multiple human disorders, such as neurological diseases, systemic amyloidosis, type II diabetes, etc. Despite significant progress in understanding the cytotoxic action of amyloid aggregates, the role of protein-fibril interactions in the amyloid toxicity remains obscure. To fill this gap, in the present study the fluorescence and molecular docking techniques have been used to investigate the interactions between the insulin fibrils (InsF) and a globular cationic protein lysozyme (Lz), known for its antibacterial, antiviral, immunomodulatory, antitumor and antiinflammatory activities.

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Опубліковано

2022-06-29

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